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General pathways of pain sensation and the major neurotransmitters involved in pain regulation


Yam, Mun Fei and Loh, Yean Chun and Tan, Chu Shan and Adam, Siti Khadijah and Abd Manan, Nizar and Basir, Rusliza (2018) General pathways of pain sensation and the major neurotransmitters involved in pain regulation. International Journal of Molecular Sciences, 19 (8). pp. 1-23. ISSN 1661-6596; ESSN: 1422-0067


Pain has been considered as a concept of sensation that we feel as a reaction to the stimulus of our surrounding, putting us in harm’s way and acting as a form of defense mechanism that our body has permanently installed into its system. However, pain leads to a huge chunk of finances within the healthcare system with continuous rehabilitation of patients with adverse pain sensations, which might reduce not only their quality of life but also their productivity at work setting back the pace of our economy. It may not look like a huge deal but factor in pain as an issue for majority of us, it becomes an economical burden. Although pain has been researched into and understood by numerous researches, from its definition, mechanism of action to its inhibition in hopes of finding an absolute solution for victims of pain, the pathways of pain sensation, neurotransmitters involved in producing such a sensation are not comprehensively reviewed. Therefore, this review article aims to put in place a thorough understanding of major pain conditions that we experience—nociceptive, inflammatory and physiologically dysfunction, such as neuropathic pain and its modulation and feedback systems. Moreover, the complete mechanism of conduction is compiled within this article, elucidating understandings from various researches and breakthroughs.

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Official URL or Download Paper: https://pubmed.ncbi.nlm.nih.gov/30042373/

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.3390/ijms19082164
Publisher: MDPI
Keywords: Pain sensitization; Neurotransmitters; Nociceptive; Inflammatory; Neuropathic; Presynaptic and postsynaptic; Pain transmission; Neurons; Synaptic transmission
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 11 Mar 2021 19:32
Last Modified: 11 Mar 2021 19:32
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/ijms19082164
URI: http://psasir.upm.edu.my/id/eprint/72824
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