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Analysis of essential gene changes in MRSA and non-MRSA strains inhibited by methanolic extract correlated to membrane permeabilising peptide


Citation

Shamsudin, M. and Mohamed Alipiah, Norfarrah and Neela, Vasantha Kumari and Md Yusoff, Fatimah and Arshad, Aziz (2007) Analysis of essential gene changes in MRSA and non-MRSA strains inhibited by methanolic extract correlated to membrane permeabilising peptide. International Journal of Antimicrobial Agents, 29 (suppl.2). S634. ISSN 0924-8579

Abstract

In this study, a methanolic extract derived from a marine organism was investigated for the effect on the growth of MRSA resistant to b-lactam antibiotics. The nucleotide sequence changes of essential genes inclusive of mecA, mecR1, 16sRNA, mprF and msR of the inhibited MRSA strains were determined. A potential antibacterial peptide with activity on permeabilising the membrane of MRSA strains was investigated through a cellular bioassay.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
Publisher: Elsevier
Depositing User: Najwani Amir Sariffudin
Date Deposited: 14 Jun 2010 09:18
Last Modified: 30 Jul 2010 04:27
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/S0924-8579(07)72030-7
URI: http://psasir.upm.edu.my/id/eprint/7269
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