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Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences


Syed Saudi, Siti Noor Sakinah and Kumaran, Sharmilah Kumari and Munisvaradass, Rusheni and Mok, Pooi Ling and Chee, Hui Yee and Seenichamy, Arivudainambi and Vijayaraman, Kiruthiga P. and Higuchi, Akon and Rajan, Mariappan and Seenivasan, K. Nataraja and Marlina and Arulselvan, Palanisamy and Benelli, Giovanni and Subbiah, Suresh Kumar (2018) Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences. Pathogens and Global Health, 112 (5). 259 - 267. ISSN 2047-7724; ESSN: 2047-7732


To determine the effect of DENV (serotype 2) repeated infections on lung cells is the main goal of this study. From the result, lung histology of control BALB/c mice showed normal alveolar morphology, while vehicle control BALB/c mice highlighted a slight thickening of the alveolar septum. Lung histopathology of BALB/c mice infected twice by DENV-2 showed the presence of hemorrhage, plasma leakage and presence of hemosiderin-laden macrophages (HLMs). Notably, in the lung of BALB/c mice infected four times by DENV-2, we observed thickening and disruption of the alveolar septum, inflammatory cell infiltration, plasma leakage and increased cellularity. Megakaryocyte releasing platelets were also found into the lung alveolus. Overall, our findings showed severe histopathological damage in lungs repeatedly infected by DENV-2, allowing us to argue that they can be linked to pulmonary complication. Result also showed that the number of infections with similar total DENV-2 titer led to different histopathological changes.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
DOI Number: https://doi.org/10.1080/20477724.2018.1492765
Publisher: Taylor and Francis
Keywords: Arbovirus; Dengue fever; Hemosiderin-laden macrophages; Mosquito-borne disease; Recurrent infection; Pulmonary complication
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 09 Nov 2020 09:37
Last Modified: 09 Nov 2020 09:37
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1080/20477724.2018.1492765
URI: http://psasir.upm.edu.my/id/eprint/72600
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