Citation
Mat Amin, Nakisah and Hamdin, Muhammad Shafiq and Azarnudin, Muhd Amir Taufiq and Asari, Asnuzilawati and Abdul Rashid, Fatin Nur Ain and Mohd Nor, Siti Mariam
(2018)
Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate).
Science International, 30 (2).
309 - 301.
ISSN 1013-5316
Abstract
Acanthamoeba is a free-living amoebae that is ubiquitously present in various natural environments. In this study, several of Aaptamine derivatives (2-5) were synthesized and evaluated for their cytotoxicity effect against Acanthamoeba castellanii (IMR isolate). The Acanthamoeba viability was determine using range of concentration from 0 until 50 µg/mL for each compounds. The treatment was done for 72 hours and Eosin stainning was used to determine the cell viability. From the result obtained, Aaptamine (1) and its derivatives (2-5) have significant effect toward inhibition growth on Acanthamoeba with of 1,4-dibenzylaaptamine (5) was observed as the most potent compound as anti-amoeba agent.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Science |
| Publisher: | Publications International |
| Keywords: | Aaptamine derivatives; Acanthamoeba castellanii |
| Depositing User: | Nurul Ainie Mokhtar |
| Date Deposited: | 05 Mar 2020 03:22 |
| Last Modified: | 05 Mar 2020 03:22 |
| URI: | http://psasir.upm.edu.my/id/eprint/72164 |
| Statistic Details: | View Download Statistic |
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