UPM Institutional Repository

Cytomegalovirus replication steps and the actions of antiviral drugs


Citation

Abdullah, Ashwaq Ahmed and Balakrishnan, Krishnan Nair and Bala, Jamilu Abubakar and Abdullah, Faez Firdaus Jesse and Allaudin, Zeenatul Nazariah and Abdullah, Rasedee and Noordin, Mohamed Mustapha and Mohd Lila, Mohd Azmi (2018) Cytomegalovirus replication steps and the actions of antiviral drugs. Anti-Infective Agents, 16 (2). 80 - 95. ISSN 2211-3525; ESSN: 2211-3533

Abstract

Human cytomegalovirus (HCMV) is a beta herpesvirus that inflicts an active infection in the fetus and immunosuppressive patients. The virus encodes many proteins that work together with cellular factors to achieve virus replication. In addition to vaccines, antiviral drugs can be deployed to manipulate how the virus replicates and minimize its pathogenicity. The five antiviral drugs approved by the Food and Drug Administration (FDA) have shown adverse reactions and the antiviral drug resistance were reported. Hence, this warrants the need for urgent development of a novel antiviral drug. Detailed understanding of the virus replication steps and how cellular signals interact with these steps will be key for pharmacological developments of for anti HCMV drugs. This review summarized all the drugs that target the virus proteins and cell signals that mediate CMV replication.


Download File

[img] Text
Cytomegalovirus replication steps and the actions of antiviral drugs.pdf

Download (5kB)

Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
Institute of Bioscience
DOI Number: https://doi.org/10.2174/2211352516666180619155021
Publisher: Bentham Science Publishers
Keywords: Cytomegalovirus; Immunosuppressive patients; Congenital infection; Ganciclovir; Herpesvirus; Fomivirsen
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 05 Mar 2020 02:34
Last Modified: 05 Mar 2020 02:34
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.2174/2211352516666180619155021
URI: http://psasir.upm.edu.my/id/eprint/72163
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item