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Chemical constituents and biological activities of South East Asia marine sponges: a review


Lee, Kah Nyan and Abas, Faridah and Maulidiani and Ahmed, Mediani and Leong, Sze Wei and Ismail, Intan Safinar and Shaari, Khozirah (2019) Chemical constituents and biological activities of South East Asia marine sponges: a review. Pertanika Journal of Science & Technology, 27 (2). pp. 953-983. ISSN 0128-7680; ESSN: 2231-8526


The ocean has an exceptional resource with various groups of natural products that are potentially useful for biomedical and other applications. Marine sponges have prominent characteristic natural products with high diversity. They produce many vital therapeutic metabolites with prominent biological activities. Marine invertebrates and microbial communities are the primary producers of such metabolites. Among the richest sources of these metabolites, class Demospongiae and the order Haplosclerida and genus Xestopongiae from family Petrosiidae are of interest. This review summarizes the research that has been conducted on two classes, eight orders, twelve families and fourteen genera of marine sponges available in the South East Asia region, covering the literature of the last 20 years. Ninety-five metabolites including alkaloids, sterols, terpenoids, quinones isolated from marine sponges collected in South East Asia along with their bioactivities especially cytotoxicity and antibacterial activities were reported in this review. Chemistry and biology are highly involved in studying marine sponges. Thus, tight collaboration is needed for understanding their taxonomy aspects. This review will outline chemistry and biological aspects, challenge, limitation, new idea and a clear future perspective on the discovery of new drugs from South East Asia's marine sponges.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
Faculty of Science
Institute of Bioscience
Publisher: Universiti Putra Malaysia Press
Keywords: Bioactivities; Chemistry; Marine sponges; South East Asia
Depositing User: Nabilah Mustapa
Date Deposited: 10 Jun 2019 03:00
Last Modified: 10 Jun 2019 03:00
URI: http://psasir.upm.edu.my/id/eprint/68705
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