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Post-weaning exposure to bisphenol A induces histological changes in the liver


Mohamad Zaid, Siti Sarah and Rohim, Siti Nur Hajar and Goh, Yong Meng and Mohamed Mustapha, Noordin (2019) Post-weaning exposure to bisphenol A induces histological changes in the liver. Pertanika Journal of Science & Technology, 27 (2). pp. 943-951. ISSN 0128-7680; ESSN: 2231-8526


Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) widely used in industry as a plasticizer for the production of polycarbonate plastics and epoxy resins. The liver is highly sensitive to BPA, even at low doses. The objective of the study is to investigate the effect of BPA on histo-architecture of the liver in post-weaning rats. Post-weaning female rats were exposed to BPA by oral gavage over a six weeks period. The results showed that even at low environmental doses, BPA exposure had adverse effects on the liver histo-architecture, thereby disrupting the functions of cellular. The administration of BPA resulted in severe hepatocytes necrosis, dilated sinusoid, and depicting features of conspicuous Kupffer cells. The results may be due to the generation of reactive oxygen species (ROS) by BPA. In conclusion, post-weaning exposure of BPA resulted in significant histological alterations due to ROS generation.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Environmental Studies
Faculty of Veterinary Medicine
Publisher: Universiti Putra Malaysia Press
Keywords: Bisphenol A; Histology; Liver; Oxidative stress; Plastic
Depositing User: Nabilah Mustapa
Date Deposited: 10 Jun 2019 03:00
Last Modified: 10 Jun 2019 03:00
URI: http://psasir.upm.edu.my/id/eprint/68704
Statistic Details: View Download Statistic

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