Citation
Ismail, Mohd Iswadi and M., Suwaibah and Tan, S. W. and Bejo, Mohd Hair and Omar, Abdul Rahman
(2018)
Sequence analysis of S1 gene of Malaysian infectious bronchitis virus variant and QX-like strains following serial passage in specific-pathogen-free embryonated chicken eggs.
In: 3rd World's Poultry Science Association (Malaysia Branch) and World Veterinary Poultry Association (Malaysia Branch) Scientific Conference 2018, 18-19 Apr. 2018, Faculty of Veterinary Medicine, Universiti Putra Malaysia and Kuala Lumpur Convention Centre, Kuala Lumpur. (pp. 51-53).
Abstract
Infectious bronchitis virus (IBV) causes infectious bronchitis (IB) disease in chickens is primarily a disease associated with respiratory tract. However, depending on virus strains, IBV can also infect the gut, reproductive and kidney of chickens. Controlling the disease is problematic because of the presence of diverse serotypes and strains, and poor cross-protection against different serotypes/strains. Recently, we have characterized the IBV strains circulating in Malaysia. Two of the prevalent strains, Malaysian local variant (MLV) (IBS037A/2014) and QX-like (IBS130/2015) were attenuated by serial passage of the virus in SPF embryonated chicken eggs. The virus strains at different passages were characterized based on sequence analysis of the partial S1 gene. Overall, IBS130/2015 showed a higher number of nucleotide and amino acid variations compared to IBS037A/2014 following serial passage in embryonated chicken eggs.
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