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The association of FDG-PET (SUVmax) and inflammatory marker in predicting tumour aggressiveness


Ahmad Saad, Fathinul Fikri and Abdullah, Noraini Sarina and Shaharuddin, Shazreen and Nordin, Abdul Jalil (2018) The association of FDG-PET (SUVmax) and inflammatory marker in predicting tumour aggressiveness. Pertanika Journal of Science & Technology, 26 (3). pp. 953-964. ISSN 0128-7680; ESSN: 2231-8526

Abstract / Synopsis

Chronic inflammation is associated with processes that contribute to the onset or progression of cancer. This study examined the correlation between dichotomised patients with malignant tumours and inflammatory markers based on the altered glucose metabolism measured by the FDG SUVmax that underpins the degree of tumour aggressiveness. Thirty-one patients underwent 18F-FDG PET/CT for various carcinoma along with blood inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL6), lipid profile and fasting blood glucose (FBG) levels were obtained in retrospective study. Patients were dichotomised by the cut-off SUVmax value of 6.0 dl/ml derived from curve analysis (P=-0.025). The mean age of the subjects were 53.16 ± 12.06 years and mean SUVmax of 8.80±6.27 g/ml. Significant correlation was noted between the SUVmax and CRP and IL6 (r=0.361; P<0.05) and IL-6 with BMI and FBG with r=0.38; p<0.05 and r=0.34; p<0.05 respectively. The odds ratio (95% confidence intervals) for patients with the SUVmax cut-off 6.0dl/ml was predicted by FBG (OR:0.385, p<0.05) and the SUVmax > 6.0 dl/ml was inversely related to IL-6 (OR: 0.049, with p<0.005). Serum inflammatory markers and endogenous glucose are associated with a potentially more aggressive malignant cancer. In particular, IL6 may be used as a useful surrogate marker for tumour aggressiveness with an important prognostic value.

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Additional Metadata

Item Type: Article
Divisions: Centre For Diagnostic Nuclear Imaging
Faculty of Medicine and Health Science
Publisher: Universiti Putra Malaysia Press
Keywords: Inflammation; Computed tomography; Positron emission tomography; [18F]-fluorodeoxyglucose; Multimodality
Depositing User: Nabilah Mustapa
Date Deposited: 12 Feb 2019 15:04
Last Modified: 12 Feb 2019 15:04
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