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Platelet transcriptome-based approaches in the fight against dengue and other diseases


Suppiah, Jeyanthi and Syed, Sakinah and Chan, Shie Yien and Wong, Yien Ping and Bala, Jamilu Abubakar and Lawal, Nafi'u and Benelli, Giovanni and Subbiah, Suresh Kumar and Chee, Hui Yee (2018) Platelet transcriptome-based approaches in the fight against dengue and other diseases. Pertanika Journal of Science & Technology, 26 (3). pp. 933-946. ISSN 0128-7680; ESSN: 2231-8526


Human platelets are anucleate cells that lack in deoxyribonucleic acid (DNA), thus hampering genomic study on them. However, the presence of their own messenger ribonucleic acid (mRNA) transcript allows functional study via the transcriptome approach. Transcriptome not only allows profiling of platelet but also aids in studying gene regulation in virus infections and other diseases that have an impact on platelets. Some viruses are known to affect the platelet either by causing a reduction or destruction. Dengue virus is one of the most postulated virus having such effect and frequently linked to platelet reduction. The transcriptome approach has a pivotal role in providing a deeper insight to link certain diseases and their effect on platelets. This review critically discusses role of platelet in dengue and other viral diseases of public health relevance, with a specific focus on the methods currently used in platelet transcriptome profiling.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Veterinary Medicine
Publisher: Universiti Putra Malaysia Press
Keywords: Anucleate cells; Arbovirus; Dengue; Platelet transcriptome profiling; Viral diseases
Depositing User: Nabilah Mustapa
Date Deposited: 12 Feb 2019 07:04
Last Modified: 12 Feb 2019 07:04
URI: http://psasir.upm.edu.my/id/eprint/66302
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