Citation
A. K., Arifah and Hong, W. S. T. and M. J., Azlina and S., Nadzri and Wai, Y. H.
(2004)
The effect of non-steroidal anti-inflammatory drugs on carrageenan-induced paw oedema in rats.
In: 11th International Conference of the Association of Institutions for Tropical Veterinary Medicine and 16th Veterinary Association Malaysia Congress, 23-27 Aug. 2004, Sunway Pyramid Convention Centre, Petaling Jaya, Malaysia. (pp. 346-347).
Abstract
Ketoprofen, meloxicam, celecoxib and rofecoxib were used in the present study to investigate the effects of NSAIDs on carrageenan-induced paw oedema in rats. Acute inflammation was induced by subplantar injection of carrageenan (0.1 ml, 1 % w/v) into the rat hind paw. Celecoxib (10 mg/kg) caused significant and prolong inhibition of rat paw oedema up to four hours. Treatment of rats with ketoprofen (1 mg/kg) significantly suppressed paw oedema volume at 2, 3 and 4 hour. Meloxicam at (0.2 mg/kg) also significantly inhibited paw oedema at first three hours. Rofecoxib (10 mg/kg) was only effective in inhibiting the paw oedema volume at 2 and 3 hours.
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