UPM Institutional Repository

Regulation of bursa immune response by velogenic NDV


Teo, Kristeen Ye Wen and Yeap, Swee Keong and Tan, Sheau Wei and Omar, Abdul Rahman and Ideris, Aini and Tan, Soon Guan and Mohammed Alitheen, Noorjahan Banu (2015) Regulation of bursa immune response by velogenic NDV. In: World Veterinary Poultry Association (Malaysia Branch) and World's Poultry Science Association (Malaysia Branch) Scientific Conference 2015, 21-22 Sept. 2015, Kuala Lumpur Convention Centre, Kuala Lumpur, Malaysia. (pp. 210-211).


Newcastle disease virus (NDV) has been well characterised and classified. We have reported the differential regulation of cytokines/chemokines expression in spleen post-infected with genotype VII and VIII NDV. To further understand the regulation of adaptive immunity by these strains of NDV, we compared the viral load, cytokines expression and oxidative stress in bursa of infected chicken. Genotype VII IBS002 was recorded with higher viral load in bursa of infected chicken comparing to genotype VIII AF2240. Although both strains of NDV upregulated proinflammatory cytokines (IFN-ɣ, CXCLi2 and IL-18) expression and nitric oxide in bursa of infected chicken, level of upregulation was greater in the bursa of AF2240 infected chicken. These findings supporting the idea of acute infection by AF2240, which resulted to earlier mortality than chicken infected with IBS002.

Download File

[img] Text
Restricted to Repository staff only

Download (256kB)

Additional Metadata

Item Type: Conference or Workshop Item (Paper)
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Faculty of Veterinary Medicine
Institute of Bioscience
Publisher: Faculty of Veterinary Medicine, Universiti Putra Malaysia
Keywords: Newcastle disease; Bursa of fabricus
Depositing User: Nabilah Mustapa
Date Deposited: 03 Sep 2018 04:49
Last Modified: 03 Sep 2018 04:49
URI: http://psasir.upm.edu.my/id/eprint/65047
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item