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Carboxymethyl sago starch based hydrogel for drug delivery application


Nordin, Nurul Aida and Abdul Rahman, Norizah (2017) Carboxymethyl sago starch based hydrogel for drug delivery application. In: 5th International Symposium on Applied Engineering and Sciences (SAES2017), 14-15 Nov. 2017, Universiti Putra Malaysia. (p. 6).


Chemically modified sago starch into carboxymethyl sago starch (CMSS) was done by using carboxymethylation reaction. The reaction times are varied to determine the optimum degree of substitution (DS) and reaction efficiency (RE). CMSS prepared via carboxymethylation for 3 hours show the highest DS and RE. The CMSS hydrogel was prepared using citric acid as cross-linker. The effects of the preparation condition of CMSS hydrogel such as the percentage of citric acid (w/w), cross-linking periods and cross-linking temperature on the gel fraction were investigated. The swelling study was carried out in distilled water, acidic, neutral and alkaline medium. The release behaviour of methylene blue (MB) as the drug model demonstrates that CMSS hydrogel has potential to be use in drug delivery applications.

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Additional Metadata

Item Type: Conference or Workshop Item (Poster)
Divisions: Faculty of Science
Keywords: Carboxymethyl sago starch; Citric acid; Hydrogel; Drug delivery; Controlled release
Depositing User: Nabilah Mustapa
Date Deposited: 05 Jul 2018 09:29
Last Modified: 05 Jul 2018 09:29
URI: http://psasir.upm.edu.my/id/eprint/64411
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