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Phytochemicals and cytotoxic studies of Zingiber cassumunar Roxb.


Citation

Azid, Mohd Zulkhairi and Sukari, Mohd Aspollah and Ee, Gwendoline Cheng Lian and Abdul, Ahmad Bustamam (2017) Phytochemicals and cytotoxic studies of Zingiber cassumunar Roxb. Journal of Tropical Agriculture and Food Science, 45 (2). pp. 187-197. ISSN 1394-9829; ESSN: 2289-9650

Abstract / Synopsis

Zingiber cassumunar belongs to the family Zingiberaceae and is locally known as ‘bonglai’ in Malay and ‘plai’ among Thais. It has been traditionally used as treatment for women after giving birth or during confinement. Extraction and isolation of phytochemical compounds from the rhizome of Zingiber cassumunar Roxb. using various chromatographic techniques identified five compounds, namely, cis-3-(3’,4’-dimethoxyphenyl)-4-[(E)-3’’’,4’’’-dimethoxystyryl]cyclo-hex- 1-ene (1), (E)-4-(3’,4’-dimethoxyphenyl) but-3-en-1-ol (2), 3,4-dimethoxybenzoic acid (3), 8-(13,14-dimethoxyphenyl)-2-methoxynaphto-1,4-quinone (4) and β-sitosterol (5). Structure elucidation of these compounds was carried out by various spectroscopic means. The cytotoxic activity of isolated compounds against human T-acute lymphoblastic leukemia cancer cells (CEMss) and human cervical cancer cells (HeLa) were carried out using MTT assay. Only the chloroform extract showed strong activity against CEMss cancer cells with IC50 values of 9.20 ± 0.02 μg/ml. Compounds (1), (2) and (4) showed strong cytotoxicity activity against HeLa cancer cells with IC50 values <15 μg/ml whilst compounds (1) and (4) demonstrated moderate cytotoxicity activity against CEMss cells with 1C50 values of 28.34 ± 0.39 μg/ml and 25.96 ± 0.94 μg/ml respectively. Therefore, Zingiber cassumunar has high potential to be commercially domesticated based on the anti-cancer properties of its compounds.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
Institute of Bioscience
Publisher: Malaysian Agricultural Research and Development Institute (MARDI)
Keywords: Zingiberaceae; Cytotoxicity; Phenylbutenoid; Ginger; Bonglai; CEMss; HeLa
Depositing User: Nabilah Mustapa
Date Deposited: 11 Jun 2018 16:17
Last Modified: 11 Jun 2018 16:17
URI: http://psasir.upm.edu.my/id/eprint/64083
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