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Zerumbone alleviates neuropathic pain through the involvement of L-arginine-nitric oxide-cGMP-K+ ATP channel pathways in chronic constriction injury in mice model


Citation

Zulazmi, Nurul Atiqah and Gopalsamy, Banulata and Chia, Jasmine Siew Min and Farouk, Ahmad Akira Omar and Sulaiman, Mohd Roslan and Bharatham, B. Hemabarathy and Perimal, Enoch Kumar (2017) Zerumbone alleviates neuropathic pain through the involvement of L-arginine-nitric oxide-cGMP-K+ ATP channel pathways in chronic constriction injury in mice model. Molecules, 22 (4). art. no. 555. pp. 1-14. ISSN 1420-3049

Abstract

The present study investigates the involvement of the l-arginine-Nitric Oxide-cGMP-K⁺ ATP pathways responsible for the action of anti-allodynic and antihyperalgesic activities of zerumbone in chronic constriction injury (CCI) induced neuropathic pain in mice. The role of l-arginine-NO-cGMP-K⁺ was assessed by the von Frey and the Randall-Selitto tests. Both allodynia and hyperalgesia assessments were carried out on the 14th day post CCI, 30 min after treatments were given for each respective pathway. Anti-allodynic and antihyperalgesic effects of zerumbone (10 mg/kg, i.p) were significantly reversed by the pre-treatment of l-arginine (10 mg/kg), 1H [1,2,4]Oxadiazole[4,3a]quinoxalin-1-one (ODQ), a soluble guanosyl cyclase blocker (2 mg/kg i.p.) and glibenclamide (ATP-sensitive potassium channel blocker) (10 mg/kg i.p.) (p < 0.05). Taken together, these results indicate that systemic administration of zerumbone produces significant anti-allodynic and antihyperalgesic activities in neuropathic pain in mice possibly due to involvement of the l-arginine-NO-cGMP-PKG-K⁺ ATP channel pathways in CCI model.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.3390/molecules22040555
Publisher: MDPI
Keywords: NO-cGMP pathway; Chronic constriction injury (CCI); Neuropathic pain; Nitric oxide; Zerumbone
Depositing User: Mohd Hafiz Che Mahasan
Date Deposited: 30 Nov 2018 04:15
Last Modified: 30 Nov 2018 04:15
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/molecules22040555
URI: http://psasir.upm.edu.my/id/eprint/63742
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