Citation
Nor, Siti Mariam Mohd and Osman, Fatin Nurul Atiqah and Ahmad, Kartini and Nafiah, Mohd Azlan
(2017)
Synthesis of N-Alkylated and N-Acylated derivatives of girinimbine.
Asian Journal of Chemistry, 29 (4).
801 - 804.
ISSN 0970-7077; ESSN: 0975-427X
Abstract
Girinimbine, a carbazole alkaloid has drawn an attention due to its wide range of pharmacological effects such as antiplatelet, antibacterial and anticancer activities. Five new derivatives of girinimbine were successfully semi-synthesized via modification on N-terminal of naturally isolated girinimbine. N-Benzylgirinimbine, N-butylgirinimbine and N-isopentylgirinimbine were obtained from alkylation reaction, whereas, N-butyrylgirinimbine and N-methylbutyrylgirinimbine were obtained from acylation reaction. The structures of synthesized girinimbine derivatives were confirmed by spectroscopic techniques.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Science |
| DOI Number: | https://doi.org/10.14233/ajchem.2017.20316 |
| Publisher: | Asian Publication Corporation |
| Keywords: | Alkylation; Carbazole; Girinimbine; N-Derivative |
| Depositing User: | Mohd Hafiz Che Mahasan |
| Date Deposited: | 16 Oct 2018 00:26 |
| Last Modified: | 16 Oct 2018 00:26 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.14233/ajchem.2017.20316 |
| URI: | http://psasir.upm.edu.my/id/eprint/63365 |
| Statistic Details: | View Download Statistic |
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