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Glucosinolates and isothiocyanates: cancer preventive effects


Abdull Razis, Ahmad Faizal and Arumugam, Asvinidevi and Konsue, Nattaya (2017) Glucosinolates and isothiocyanates: cancer preventive effects. In: Fruit and Vegetable Phytochemicals: Chemistry and Human Health. John Wiley & Sons, 199 - 210. ISBN 9781119157946; EISBN: 9781119158042


The anticarcinogenic bioactivity of various isothiocyanates (ITCs) has been demonstrated in various animal models such as rats, mice, and hamsters, and in different target tissues such as lung, esophagus, and forestomach. A major chemopreventive mechanism of ITCs involves suppression of reactive metabolite generation and, therefore, a decrease in DNA adducts formation. Many in vitro studies have reported the effects of ITCs on cell cycle modulation and proapoptotic effects through a number of targets, at different points of the pathways. A comparative study in human subjects showed that the hydrolysis of glucosinolates and the absorption of ITCs are greater following ingestion of raw brassica with active plant myrosinase than after consumption of the cooked plant with denatured myrosinase. Apoptosis is considered a vital component of the cellular mechanisms responsible for the maintenance of homeostasis in multicellular organisms. Understanding the pathways of associated proteins provides an insight into the induction of apoptosis by anticancer agents.

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Additional Metadata

Item Type: Book Section
Divisions: Faculty of Food Science and Technology
DOI Number: https://doi.org/10.1002/9781119158042.ch11
Publisher: John Wiley & Sons
Keywords: Anticarcinogenic bioactivity; Apoptosis; Cancer preventive effects; Cell cycle modulation; Glucosinolates; Human dietary exposure human; Health isothiocyanates
Depositing User: Azhar Abdul Rahman
Date Deposited: 13 Nov 2019 06:22
Last Modified: 13 Nov 2019 06:22
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1002/9781119158042.ch11
URI: http://psasir.upm.edu.my/id/eprint/63117
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