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Monoclonal antibodies: a review of therapeutic applications and future prospects


Mahmuda, Aliyu and Bande, Faruku and Al-Zihiry, Khalid Jameel Kadhim and Abdulhaleem, Noor and Abd Majid, Roslaini and Awang Hamat, Rukman and Abdullah, Wan Omar and Unyah, Ngah Zasmy (2017) Monoclonal antibodies: a review of therapeutic applications and future prospects. Tropical Journal of Pharmaceutical Research, 16 (3). pp. 713-722. ISSN 1596-5996; ESSN: 1596-9827


The increasing demand for monoclonal antibodies (mAbs) used for diagnostic and therapeutic applications has led to the development of large scale manufacturing processes, with improvements in production achieved through continuous optimization of the inherent systems. The number of monoclonal antibodies (mAbs) that have already been approved for therapeutic applications and for use in clinical trials have significantly increased in the past few years. In view of the side effects and limitations of mAbs, several improvements and modifications to monoclonal antibodies have been developed. These modifications have facilitated the use of mAbs in various forms of therapeutic applications such as treatment of infectious diseases caused by bacterial, viral, fungal and parasitic organisms. Monoclonal antibodies have also been applied in the treatment of non-infectious diseases such as cancer, immune diseases, arthritis and other disorders resulting from organ transplantation. This review highlights mAbs applications in biomedicine, and discusses state-of-the-art technologies related to their potential uses.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Veterinary Medicine
DOI Number: https://doi.org/10.4314/tjpr.v16i3.29
Publisher: University of Benin
Keywords: Monoclonal antibodies; Therapeutic application; Infectious diseases; Cancer; Auto-immune diseases; Metabolic disorders
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 03 Dec 2020 20:57
Last Modified: 03 Dec 2020 20:57
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.4314/tjpr.v16i3.29
URI: http://psasir.upm.edu.my/id/eprint/62479
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