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Control of haemonchosis in Malaysian goats with closantel


Citation

Dorny, Pierre and Vercruysse, Jozef and Abu, Jalila and Abdullah Sani, Rehana and Symoens, Chantal (1994) Control of haemonchosis in Malaysian goats with closantel. Veterinary Parasitology, 53 (3-4). pp. 223-241. ISSN 0304-4017

Abstract / Synopsis

The therapeutic and prophylactic effects of closantel on natural infections with Haemonchus contortus were studied in goats in Peninsular Malaysia. Closantel was highly effective against H. contortus, either at a subcutaneous (s.c.) injection of 5.0 mg kg- ~ body weight (100%), or in an oral drench mixture with mebendazole at a dose of 10.0 mg kg-(99.2%), as indicated by faecal egg counts. H. contortus larvae were absent from faecal cultures for 5, 6 and 7 weeks following treatment with s.c. injections of closantel at doses of 2.5 mg kg- 1, 5.0 mg kg- ~ and 10.0 mg kg- 1 respectively, and for 6 weeks after treatment with closantel at 10.0 mg kg -1, given orally. Through its sustained activity, closantel not only prevented reinfection with H. contortus but also caused a dramatic reduction in pasture contamination. The potential utility of closantel in the strategic control of haemonchosis in goats, and as an alternative treatment for benzimidazoles and levamisole resistant H. contortus strains, is discussed.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
DOI Number: https://doi.org/10.1016/0304-4017(94)90186-4
Publisher: Elsevier Science
Keywords: Haemonchus contortus, Goat, Control methods-Nematoda, Closantel, Sustained activity
Depositing User: Azizan Arshad
Date Deposited: 12 May 2010 04:50
Last Modified: 12 Nov 2015 08:46
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/0304-4017(94)90186-4
URI: http://psasir.upm.edu.my/id/eprint/6245
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