UPM Institutional Repository

Mesenchymal stem cell-mediated T cell immunosuppression


Al-Graittee, Satar Jabbar Rahi and Lawal, Hamza and Ramasamy, Rajesh (2017) Mesenchymal stem cell-mediated T cell immunosuppression. Stem Cell: Advanced Research and Therapy, 2017 (3). pp. 1-5. ISSN 2637-9589


Besides being a pool forstromal cells and connective tissues, the mesenchymal stem cells (MSCs) as well exert a potent immunosuppression against almost all types of immune cells, particularly T cells. Many in vitro and in vivo studies revealed that the reported regenerative property of MSCs is partially due to the immunosuppressive activity of MSCs where it creates an optimal microenvironment for the execution of reparative and restorative processes. To date, MSCs caninteract with nearly all cells of the immune system, in a convoluted mechanism with theabilityof inhibiting the activation, proliferation, and function of T cells. These characteristicsshowcaseMSCs’ candidature as anaturalimmunosuppressive agent in regenerative medicine, therapies for immune disorders and tissue engineering. In this review, the intricate mechanisms of MSC-mediated immunosuppression on Tcellswere briefly evaluated. The physical, paracrine and molecular interactions that being toolsfor delivering the immunosuppressionwere also highlighted.

Download File

[img] Text
Mesenchymal stem cell-mediated T cell immunosuppression.pdf

Download (144kB)

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.29011/SCRT-119. 000019
Publisher: Gavin Publishers
Keywords: Mesenchymal stem cell; T cell; Immunosuppression; Immune cells
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 10 Jan 2020 04:14
Last Modified: 10 Jan 2020 04:14
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.29011/SCRT-119. 000019
URI: http://psasir.upm.edu.my/id/eprint/62394
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item