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Light chain multiple myeloma: an evaluation of its biochemical investigations


Zahari Sham, Siti Yazmin and Chellappah Thambiah, Subashini and Samsudin, Intan Nureslyna and Lim, Say Min (2017) Light chain multiple myeloma: an evaluation of its biochemical investigations. The Malaysian Journal of Pathology, 39 (3). 311 - 315. ISSN 0126-8635


Multiple myeloma is a type of plasma cell dyscrasia, characterised by presence of paraprotein or monoclonal (M)-protein in serum or urine. The M-protein may consist of an intact immunoglobulin, the heavy chain only or the light chain only. The latter, designated as light chain multiple myeloma (LCMM) makes up almost 20% of myelomas. Clinical manifestation is often heralded by hypercalcaemia, renal impairment, normocytic normochromic anaemia and bone lesions, reflecting end-organ damage, collectively known as the acronym CRAB. In particular, free light chain nephrotoxicity accounts for the high prevalence of renal impairment seen in LCMM. This case illustrates a typical presentation of LCMM with focal discussion on its initial and diagnostic, as well as prognostic biochemical investigations.

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Official URL or Download Paper: http://www.mjpath.org.my/2017/v39n3/index.php

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Malaysian Society of Pathologists
Keywords: Light chain multiple myeloma; Diagnosis; Prognosis; Biochemical investigations
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 31 Oct 2019 02:34
Last Modified: 31 Oct 2019 02:34
URI: http://psasir.upm.edu.my/id/eprint/62306
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