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In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb


Citation

Wahyuni, Fatma Sri and Lim, Siang Hui and Stanslas, Johnson and Lajis, Nordin and Hamidi, Dachriyanus (2017) In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb. Journal of Young Pharmacists, 9 (2). 296 - 298. ISSN 0975-1483; ESSN: 0975-1505

Abstract

Objective: To investigate the in vivo antitumor effect of TPTQ against H-460 lung cancer cell lines in nude mice. Materials and Methods: Female nude mice bearing H-460 tumor at size approximately 5 mm in diameter were treated with a single intraperitoneal dose 800 mg/kg of TPTQ. The vehicletreated (10% tween 80) animals were used as control group. The tumor size and mice body weight were measured for 14 days. Results: Single treatment of 800 mg/kg of TPTQ displayed moderate antitumor activity against H-460 tumor xenografts as compared with vehicle-treated control. The mean time to reach RTV of 4 for vehicle-treated control group was 4.5 days whereas for TPTQ-treated (800 mg/kg) group was 9.5 days. Conclusion: The results showed that TPTQ slowed the tumor growth by 5 days. Thus, TPTQ may be considered as a promising compound in cancer chemotherapy.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.5530/jyp.2017.9.58
Publisher: Wolters Kluwer - Medknow Publications and Media
Keywords: Tetrapreniltoluquinone; Lung cancer; Nude mice; H-460; Xenografts
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 16 Apr 2019 03:51
Last Modified: 16 Apr 2019 03:51
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.5530/jyp.2017.9.58
URI: http://psasir.upm.edu.my/id/eprint/62141
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