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Impact of physical activity on cognitive decline, dementia and its subtypes: meta-analysis of prospective studies


Guure, Chris Bambey and Ibrahim, Noor Akma and Adam, Mohd Bakri and Md Said, Salmiah (2017) Impact of physical activity on cognitive decline, dementia and its subtypes: meta-analysis of prospective studies. BioMed Research International, 2017. art. no. 9016924. pp. 1-13. ISSN 2314-6133; ESSN: 2314-6141


The association of physical activity with dementia and its subtypes has remained controversial in the literature and has continued to be a subject of debate among researchers. A systematic review and meta-analysis of longitudinal studies on the relationship between physical activity and the risk of cognitive decline, all-cause dementia, Alzheimer’s disease, and vascular dementia among nondemented subjects are considered. A comprehensive literature search in all available databases was conducted up until April 2016. Well-defined inclusion and exclusion criteria were developed with focus on prospective studies ≥ 12 months. The overall sample from all studies is 117410 with the highest follow-up of 28 years. The analyses are performed with both Bayesian parametric and nonparametric models. Our analysis reveals a protective effect for high physical activity on all-cause dementia, odds ratio of 0.79, 95% CI (0.69, 0.88), a higher and better protective effect for Alzheimer’s disease, odds ratio of 0.62, 95% CI (0.49, 0.75), cognitive decline odds ratio of 0.67, 95% CI (0.55, 0.78), and a nonprotective effect for vascular dementia of 0.92, 95% CI (0.62, 1.30). Our findings suggest that physical activity is more protective against Alzheimer’s disease than it is for all-cause dementia, vascular dementia, and cognitive decline.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Science
Institute for Mathematical Research
DOI Number: https://doi.org/10.1155/2017/9016924
Publisher: Hindawi Publishing Corporation
Keywords: Physical activity; Dementia; Cognitive decline
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 05 Apr 2019 05:49
Last Modified: 05 Apr 2019 05:49
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2017/9016924
URI: http://psasir.upm.edu.my/id/eprint/62102
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