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Hemogram responses in goats toward challenged with Corynebacterium pseudotuberculosis and its immunogen mycolic acids


Citation

Ahmed Odhah, Mohammed Naji and Abdullah, Faez Firdaus Jesse and Haron, Abd Wahid and Mohd. Lila, Mohd. Azmi and Saad, Mohd. Zamri and Khuder, Zaid and Hambali, Idris Umar and Umar, Muhammed and Mohammed Saleh, Wessam Monther (2017) Hemogram responses in goats toward challenged with Corynebacterium pseudotuberculosis and its immunogen mycolic acids. Veterinary World, 10 (6). 655 - 661. ISSN 0972-8988; ESSN: 2231-0916

Abstract / Synopsis

Aim: This study was conducted to analyze the changes in blood profile of goats inoculated with Corynebacterium pseudotuberculosis and its immunogen mycolic acid (MA) extract. Materials and Methods: A total of 12 clinically healthy crossbred Boer female goats were divided into three groups; A, B and C (4 goats each per group). Group A was inoculated with 2 ml sterile phosphate buffered saline via intradermal route as the negative control group whilst Group B was inoculated with 2 ml of MA extract (1 g/ml) intradermally and Group C was then inoculated with 2 ml (1×109) colony forming unit of active C. pseudotuberculosis intradermally. Blood sample was collected aseptically from the jugular vein periodically for complete blood count (CBC) analysis throughout the experimental period (3 months). Result: A significant decrease (p<0.05) was observed in red blood cells, hemoglobin (Hb), packed cell volume, mean corpuscular volume and mean corpuscular Hb concentration in Groups B and C as compared to the control while WBCs, neutrophil, lymphocyte and basophil showed a significant increase (p<0.05) as compared to the control. Conclusion: The inoculation of C. pseudotuberculosis and MA resulted in a significant change in the CBC, thereby, indicating that MA has a role in caseous lymphadenitis pathogenesis.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
DOI Number: https://doi.org/10.14202/vetworld.2017.655-661
Publisher: Veterinary World
Keywords: Complete blood count; Corynebacterium pseudotuberculosis; Goat; Hematology; Mycolic acid
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 18 Mar 2019 12:13
Last Modified: 18 Mar 2019 12:13
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.14202/vetworld.2017.655-661
URI: http://psasir.upm.edu.my/id/eprint/62022
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