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Evaluation of direct esterification of fatty acid derivative of Kojic acid in co-solvent system: a statistical approach


Citation

Ahmad Norddin, Fatin Amirah and Syed Azhar, Sharifah Nurfadhlin Afifah and Ashari, Siti Efliza (2017) Evaluation of direct esterification of fatty acid derivative of Kojic acid in co-solvent system: a statistical approach. Journal of Chemical Engineering and Process Technology, 8 (2). pp. 1-6. ISSN 2157-7048

Abstract / Synopsis

The present work deals with direct esterification method to synthesize Kojic acid using immobilized lipase as a biocatalyst in acetonitrile with the addition of dimethylsulfoxide (DMSO) as a solubilizing agent Co-solvent respectively. To increase the esterification yield of KMO, modifications of the process were evaluated, including the use of a cosolvent and the use of Novozyme 435 (Candida antarctica) as a catalyst. The KMO synthesis has been developed and optimized by using Response Surface Methodology (RSM) with Central Composite Rotatable Design (CCRD). The optimized condition of enzyme was 3.35 wt% and 1:3.64 molar ratio of kojic acid and oleic acid at 82.39°C for 255.24 min of reaction. With these condition, the maximum percentage yield was 42.73% with R2 value of 0.866914 and indicated that 86.69% of the variability in the response could be explained by the model. The model was significant and fitted well with the experimental data and the lack of fit was not significant. The efficacy for cosmetic application was successfully tested and showed as non-irritating with a Human Irritancy Equivalent score between 0.55-0.83 which safe to be applied in cosmetic ingredient.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
DOI Number: https://doi.org/10.4172/2157-7048.1000331
Publisher: Omics Publishing
Keywords: Kojic acid; Kojic ester; Esterification; Co-solvent; Response surface methodology
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 23 Jan 2019 16:30
Last Modified: 23 Jan 2019 16:30
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.4172/2157-7048.1000331
URI: http://psasir.upm.edu.my/id/eprint/61783
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