UPM Institutional Repository

Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules


Citation

Tan, Phui Yee and Tan, Tai Boon and Chang, Hon Weng and Tey, Beng Ti and Chan, Eng Seng and Lai, Oi Ming and Baharin, Badlishah Sham and Nehdi, Imededdine Arbi and Tan, Chin Ping (2017) Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules. Journal of Agricultural and Food Chemistry, 65 (48). 10651 - 10657. ISSN 0021-8561

Abstract

Considering the health benefits of tocotrienols, continuous works have been done on the encapsulation and delivery of these compounds. In this study, we encapsulated tocotrienols in chitosan-alginate microcapsules and evaluated their release profile. Generally, these tocotrienols microcapsules (TM) displayed high thermal stability. When subjected to pH adjustments (pH 1–9), we observed that the release of tocotrienols was the highest (33.78 ± 0.18%) under basic conditions. The TM were also unstable against the effect of ionic strength, with a high release (70.73 ± 0.04%) of tocotrienols even at a low sodium chloride concentration (50 mM). As for the individual isomers, δ-tocotrienol was the most sensitive to pH and ionic strength. In contrast, β-/γ-tocotrienols were the most ionic-stable isomers but more responsive toward thermal treatment. Simulated gastrointestinal model showed that the chitosan-alginate-based TM could be used to retain tocotrienols in the gastric and subsequently release them in the intestines for possible absorption.


Download File

[img]
Preview
Text
Effects of environmental stresses and in vitro digestion .pdf

Download (73kB) | Preview

Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Faculty of Food Science and Technology
DOI Number: https://doi.org/10.1021/acs.jafc.7b03521
Publisher: American Chemical Society
Keywords: Alginate; Chitosan; Gelation; Microencapsulation; Release profile; Self-assembled
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 24 Oct 2018 08:11
Last Modified: 24 Oct 2018 08:11
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1021/acs.jafc.7b03521
URI: http://psasir.upm.edu.my/id/eprint/61648
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item