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Directly observed therapy for clozapine with concomitant methadone prescription: a method for improving adherence and outcome


Citation

Pang, Nicholas Tze Ping and Mohamad Isa, Mohd Fadzli and Suarn Singh, Vikram and Masiran, Ruziana (2017) Directly observed therapy for clozapine with concomitant methadone prescription: a method for improving adherence and outcome. BMJ Case Reports, 2017. pp. 1-3. ISSN 1757-790X

Abstract

A young male presented with many years of delusions and hallucinations, with concurrent heroin use and subsequent amphetamine uses. There were no depressive or manic symptoms and psychotic symptoms prior to the amphetamine use. After the trials of two atypical antipsychotics and later clozapine due to treatment resistance, adherence and functionality were poor and there was still persistent drug use. As a result, a long acting injectable adjunct was commenced, but only minimal effects were observed. However after initiation of directly observed treatment of clozapine with methadone, there has been functional and clinical response and drug use has ceased.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1136/bcr-2017-221048
Publisher: BMJ Group
Keywords: Drug misuse (including addiction); Drugs misuse (including addiction); Psychiatry (drugs and medicines); Schizophrenia
Depositing User: Ms. Ainur Aqidah Hamzah
Date Deposited: 30 Mar 2022 04:46
Last Modified: 30 Mar 2022 04:46
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1136/bcr-2017-221048
URI: http://psasir.upm.edu.my/id/eprint/61490
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