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Clinical predictors of dengue fever co-infected with leptospirosis among patients admitted for dengue fever - a pilot study


Citation

Suppiah, Jeyanthi and Chan, Shie Yien and Ng, Min Wern and Khaw, Yam Sim and Ching, Siew Mooi and Mat Nor, Lailatul Akmar and Ahmad Najimudin, Naematul Ain and Chee, Hui Yee (2017) Clinical predictors of dengue fever co-infected with leptospirosis among patients admitted for dengue fever - a pilot study. Journal of Biomedical Science, 24 (40). pp. 1-8. ISSN 1021-7770; ESSN: 1423-0127

Abstract

Background: Dengue and leptospirosis infections are currently two major endemics in Malaysia. Owing to the overlapping clinical symptoms between both the diseases, frequent misdiagnosis and confusion of treatment occurs. As a solution, the present work initiated a pilot study to investigate the incidence related to co-infection of leptospirosis among dengue patients. This enables the identification of more parameters to predict the occurrence of co-infection. Method: Two hundred sixty eight serum specimens collected from patients that were diagnosed for dengue fever were confirmed for dengue virus serotyping by real-time polymerase chain reaction. Clinical, laboratory and demographic data were extracted from the hospital database to identify patients with confirmed leptospirosis infection among the dengue patients. Thus, frequency of co-infection was calculated and association of the dataset with dengue-leptospirosis co-infection was statistically determined. Results: The frequency of dengue co-infection with leptospirosis was 4.1%. Male has higher preponderance of developing the co-infection and end result of shock as clinical symptom is more likely present among co-infected cases. It is also noteworthy that, DENV 1 is the common dengue serotype among all cases identified as dengue-leptospirosis co-infection in this study. Conclusion: The increasing incidence of leptospirosis among dengue infected patients has posed the need to precisely identify the presence of co-infection for the betterment of treatment without mistakenly ruling out either one of them. Thus, anticipating the possible clinical symptoms and laboratory results of dengue-leptospirosis co-infection is essential.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1186/s12929-017-0344-x
Publisher: BioMed Central
Keywords: Dengue fever; Leptospirosis; Co-infection; Shock; Serotype; Malaysia
Depositing User: Nida Hidayati Ghazali
Date Deposited: 14 May 2019 02:31
Last Modified: 14 May 2019 02:31
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1186/s12929-017-0344-x
URI: http://psasir.upm.edu.my/id/eprint/61125
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