UPM Institutional Repository

Characterisation of sol-gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro


Citation

Nordin, Noraini and Kanagesan, Samikannu and Zamberi, Nur Rizi and Yeap, Swee Keong and Abu, Nadiah and Tamilselvan, Subramani and Hashim, Mansor and Mohammed Alitheen, Noorjahan Banu (2017) Characterisation of sol-gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro. IET Nanobiotechnology, 11 (3). 343 - 348. ISSN 1751-8741; ESSN: 1751-875X

Abstract

In this study, nanocrystalline magnesium zinc ferrite nanoparticles were successfully prepared by a simple sol-gel method using copper nitrate and ferric nitrate as raw materials. The calcined samples were characterised by differential thermal analysis/thermogravimetric analysis, Fourier transform infrared spectroscopy and X-ray diffraction. Transmission electron microscopy revealed that the average particle size of the calcined sample was in a range of 17-41 nm with an average of 29 nm and has spherical size. A cytotoxicity test was performed on human breast cancer cells (MDA MB-231) and (MCF-7) at various concentrations starting from (0 µg/ml) to (800 µg/ml). The sample possessed a mild toxic effect toward MDA MB-231 and MCF-7 after being examined with MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyltetrazolium bromide) assay for up to 72 h of incubation. Higher reduction of cells viability was observed as the concentration of sample was increased in MDA MB-231 cell line than in MCF-7. Therefore, further cytotoxicity tests were performed on MDA MB-231 cell line.


Download File

[img]
Preview
Text (Abstract)
Characterisation of sol-gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro.pdf

Download (5kB) | Preview

Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Institute of Advanced Technology
Institute of Bioscience
DOI Number: https://doi.org/10.1049/iet-nbt.2016.0007
Publisher: The Institution of Engineering and Technology
Keywords: Cytotoxicity; Breast cancer
Depositing User: Nida Hidayati Ghazali
Date Deposited: 06 May 2019 08:21
Last Modified: 06 May 2019 08:21
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1049/iet-nbt.2016.0007
URI: http://psasir.upm.edu.my/id/eprint/61081
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item