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Anti-obesity potential of selected tropical plants via pancreatic lipase inhibition


Alias, Norsyuhada and Thean, Chor Leow and Mohamad Ali, Mohd Shukuri and Ahmad Tajudin, Asilah and Salleh, Abu Bakar and Raja Abd Rahman, Raja Noor Zaliha (2017) Anti-obesity potential of selected tropical plants via pancreatic lipase inhibition. Advances in Obesity, Weight Management & Control, 6 (4). pp. 122-131. ISSN 2378-3168

Abstract / Synopsis

Natural products are a vast source of potential compounds that can be developed as anti-obesity agent. One of the mechanisms of anti-obesity agents is inhibition of pancreatic lipase. Assay of 24 crude extracts for their in vitro activity against porcine pancreatic lipase (PPL) detected four extracts demonstrating high (>70%) inhibition, seven extracts had medium (30-70%) inhibition and the remaining 13 extracts exhibited low (<30%) inhibition when incubated with PPL at a concentration of 500µg/ml for 10min at 37°C. Phyllanthus niruri extract displayed the most potent PPL inhibitor, followed by Orthosiphon stamineus, Murraya paniculata and Averrhoa bilimbi with the IC50 value of 27.7<34.7< 41.5<55.2µg/ml, respectively. P. niruri & O. stamineus (the best two extracts) showed noncompetitive and uncompetitive inhibition, respectively. P. niruri & O. stamineus displayed total phenolic content of 431.0±0.01 and 103.0±0.01mg GAE/g dry extract, while total flavonoid content of 14.8±0.07 and 21.6±0.03mg QE/g dry extract, respectively. Both P. niruri & O. stamineus extracts showed high antioxidant activity, with EC50 values of 8.4 and 26.3µg/ml, respectively. The results suggest that P. niruri & O. stamineus may be beneficial for obesity treatment via pancreatic lipase inhibition action.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
DOI Number:
Publisher: MedCrave Group
Keywords: Pancreatic lipase inhibitor; Phyllanthus niruri; Orthosiphon stamineus; Obesity
Depositing User: Nida Hidayati Ghazali
Date Deposited: 25 Mar 2019 08:23
Last Modified: 25 Mar 2019 08:23
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