Simple Search:

Antiarthritic and gastroprotective activities of Ardisia crispa root partially mediated via its antioxidant effect


Citation

Abd Hamid @ Abdul Razak, Roslida and Lau, Moi Fong and Yeong, Looi Ting (2017) Antiarthritic and gastroprotective activities of Ardisia crispa root partially mediated via its antioxidant effect. Journal of Complementary and Integrative Medicine, 15 (1). ISSN 2194-6329; ESSN: 1553-3840

Abstract / Synopsis

Background Ardisia crispa Thunb A.DC (Myrsinaceae), commonly known as "hen's eyes", has been traditionally used in treating various inflammatory diseases. The present study evaluated anti-arthritic, gastroprotective and antioxidant activities of Ardisia crispa root hexane extract (ACRH) in various animal models. Methods Anti-arthritic activity was evaluated in complete Freund adjuvant (CFA)-induced adjuvant arthritis and gastroprotective effect was studied in the ethanol-induced ulcer model in rats. ACRH was further isolated to yield quinone-rich fraction (QRF) and both were analyzed for their total phenolic content, total flavonoid content and antioxidant activities in various antioxidant assays. Both ACRH and QRF were also analyzed for the quinone composition via gas chromatography analysis. Results ACRH exerted significant reduction of IL-1β and TNF-α at a lower dose range in CFA-induced arthritis, as well as exhibited its cytoprotective effect against ethanol-induced ulcer lesion via involvement of mucosal nonprotein sulfhydryl (NP-SH) groups. ACRH also showed higher phenolic and flavonoid contents, as well as better antioxidant activities than QRF. Conclusions These findings demonstrated the plant as a potential anti-inflammatory agent, with ACRH succeeded in inhibiting both arthritic and ulcerogenic effect, possibly mediated via its antioxidant effect.


Download File

[img]
Preview
PDF (Abstract)
Antiarthritic and gastroprotective activities of Ardisia crispa root partially mediated via its antioxidant effect.pdf

Download (103kB) | Preview

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1515/jcim-2017-0012
Publisher: Walter de Gruyter GmbH
Keywords: Ardisia crispa; N-ethylmaleimide; Complete freund adjuvant; Ethanol-induced ulcer; Free-radical; Quinone
Depositing User: Nida Hidayati Ghazali
Date Deposited: 26 Mar 2019 16:33
Last Modified: 26 Mar 2019 16:33
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1515/jcim-2017-0012
URI: http://psasir.upm.edu.my/id/eprint/60877
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item