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A review of the biomedical applications of zerumbone and the techniques for its extraction from ginger rhizomes


Citation

Kalantari, Katayoon and Moniri, Mona and Moghaddam, Amin Boroumand and Abdul Rahim, Raha and Ariff, Arbakariya and Izadiyan, Zahra and Mohamad, Rosfarizan (2017) A review of the biomedical applications of zerumbone and the techniques for its extraction from ginger rhizomes. Molecules, 22 (10). art. no. 1645. pp. 1-24. ISSN 1431-5157; ESSN: 1420-3049

Abstract

Zerumbone (ZER) is a phytochemical isolated from the subtropical Zingiberaceae family and as a natural compound it has different biomedical properties such as antioxidant, anti-inflammatory anti-proliferative activity. ZER also has effects on angiogenesis and acts as an antitumor drug in the treatment of cancer, showing selective toxicity toward various cancer cell lines. Several techniques also have been established for extraction of ZER from the rhizomes of ginger. This review paper is an overview of recent research about different extraction methods and their efficiencies, in vivo and vitro investigations of ZER and also its prominent chemopreventive properties and treatment mechanisms. Most of the studies mentioned in this review paper may be useful use as a knowledge summary to explain ZER extraction and anticancer activities, which will show a way for the development of strategies in the treatment of malignancies using ZER.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Institute of Tropical Forestry and Forest Products
DOI Number: https://doi.org/10.3390/molecules22101645
Publisher: MDPI
Keywords: Anticancer properties; Antimicrobial; Antioxidant; Extraction methods; Zerumbone
Depositing User: Nida Hidayati Ghazali
Date Deposited: 02 Apr 2019 02:00
Last Modified: 02 Apr 2019 02:00
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/molecules22101645
URI: http://psasir.upm.edu.my/id/eprint/60713
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