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Haruan (Channastriatus) extract as halal innovation productsfor healing of gastric ulcer: preliminary investigation


Azemi, Ahmad Khusairi and Md Tohid, Siti Farah and Somchit, Muhammad Nazrul and Mat Jais, Abdul Manan and Zakaria, Zainul Amiruddin (2014) Haruan (Channastriatus) extract as halal innovation productsfor healing of gastric ulcer: preliminary investigation. In: Malaysia International Halal Research & Education Conference 2014 (MIHREC 2014), 2-4 Dec. 2014, Marriott Putrajaya Hotel, Malaysia. (pp. 217-222).

Abstract / Synopsis

Channastriatus (Haruan), a freshwater and snakehead fish, is traditionally used by the Malay to heal wound and lessens post-operative pain and discomfort. The objective of the present study is to elucidate the gastroprotective activity of chloroform:metanol extract of C. striatus fillet. The fillets were extracted using the methanol: chloroform (2:1; v/v) solvent system. The extract (labeled as MCECS), prepared in the doses of 50, 250, and 500 mg/kg, was orally administered into rats for 7 continuous days and then the animals were subjected to the ethanol- and indomethacin-induced gastric ulcer models. Following the euthanization of treated rats, the stomach was callected for macroscopic and microscopic analysis. The results showed that oral administration of MCECS exhibited significant (p<0.05) and dose-dependent antiulcer activity when assessed using both models of gastric ulcer. In addition, the macroscopic findings were supported by the microscopic observations. In conclusion, C. striatus extract exerted remarkable antiulcer activity that warranted in-depth studies in an attempt to develop its extract as a halal-based product.

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Additional Metadata

Item Type: Conference or Workshop Item (Poster)
Divisions: Faculty of Medicine and Health Science
Halal Products Research Institute
Publisher: Halal Products Research Institute, Universiti Putra Malaysia
Keywords: Channastriatus; Haruan; Lipid-based extract; Gastroprotective activity; Halal-based product
Depositing User: Nabilah Mustapa
Date Deposited: 07 Jun 2018 16:42
Last Modified: 07 Jun 2018 16:42
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