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An update on type 1 diabetes treatments: insulin treatment, cell therapy and transplantation


Hani, Homayoun and Mohd Lila, Mohd Azmi and Abdullah, Rasedee and Allaudin, Zeenathul Nazariah and Sarsaifi, Kazhal and Abdullah, Faez Firdaus Jesse (2018) An update on type 1 diabetes treatments: insulin treatment, cell therapy and transplantation. Pertanika Journal of Science & Technology, 26 (1). pp. 71-84. ISSN 0128-7680; ESSN: 2231-8526


Diabetes is one of the major life-threatening health problems worldwide today. It is one of the most fast-growing diseases that cause many health complications and a leading cause of decreasing life expectancy and high mortality rate. Many studies have suggested several different types of intervention to treat Type 1 diabetes such as insulin therapy, islet transplantation, islet xenotransplantation and stem cell therapy. However, issues regarding the efficacy, cost and safety of these treatments are not always well addressed. For decades, diabetes treatments with few side effects and long-lasting insulin independence has remained one of the most challenging tasks facing scientists. Among the treatments mentioned above, application of human islet transplantation in patients with type 1 diabetes has progressed rapidly with significant achievement. Again, the lack of appropriate donors for islet transplantation and its high cost have led researchers to look for other alternatives. In this review, we discuss very pertinent issues that are related to diabetes treatments, their availability, advantages, disadvantages and also cost.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
Publisher: Universiti Putra Malaysia Press
Keywords: Cell therapy; Diabetes economy; Diabetes treatments; Insulin; Islet transplantation; Stem cell therapy
Depositing User: Nabilah Mustapa
Date Deposited: 12 Mar 2018 03:10
Last Modified: 12 Mar 2018 03:10
URI: http://psasir.upm.edu.my/id/eprint/59592
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