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Antitumor promoting and actioxidant activities of anthraquinones isolated from the cell suspension culture of Morinda elliptica


Citation

Jasril, and Lajis, Md. Nordin and Lim, Yang Mooi and Abdullah, Mohd Azmuddin and Sukari, Mohd Aspollah and Ali, Abdul Manaf (2003) Antitumor promoting and actioxidant activities of anthraquinones isolated from the cell suspension culture of Morinda elliptica. Asia Pacific Journal of Molecular Biology and Biotechnology, 11 (1). pp. 3-7. ISSN 0128-7451

Abstract

Six anthraquinones (nordamnacanthal, alizarin-1-methyl ether, rubiadin, soranjidiol, lucidin-ω-methyl ether and morindone) isolated from the cell suspension culture of Morinda elliptica were assayed for antitumor promoting and antioxidant activities. All compounds exhibited strong antitumor promoting activity at the concentration of 2.0 μg/ml when assayed using the inhibition test of Epstein Barr Virus (EBV) activation on Raji cells. At the concentration of 0.4 μg/ml, only nordamnacanthal exhibited strong antitumor promoting activity with the inhibition rate and the cell viability of 75.0% and 75.8%, respectively, which was stronger than the reference compounds genistein and quercetin. In antioxidant assay using ferric thiocyanate (FTC) method, nordamnacanthal and morindone showed stronger antioxidant activity than α-tocopherol. However when the compounds were assayed for scavenging activity of the stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals, only morindone was considered to be active as free radical scavenger with fifty percent inhibition concentration (IC50) of 40.6 μg/ml.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Biotechnology
Faculty of Science
Publisher: Malaysian Society for Molecular Biology and Biotechnology
Keywords: Antitumor promoting; Antioxidant; Anthraquinones; Cell suspension; Morinda elliptica
Depositing User: Nabilah Mustapa
Date Deposited: 22 Jan 2018 03:13
Last Modified: 22 Jan 2018 03:13
URI: http://psasir.upm.edu.my/id/eprint/58528
Statistic Details: View Download Statistic

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