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Alteration in morphological features of Puntius javanicus liver exposed to copper sulfate


Sabullah, Mohd Khalizan and Ahmad, Siti Aqlima and Abd. Shukor, Mohd. Yunus and Gansau, Jualang @ Azlan Abdullah and Shamaan, Nor Aripin and Khalid, Ariff and Sulaiman, Mohd Rosni (2017) Alteration in morphological features of Puntius javanicus liver exposed to copper sulfate. International Food Research Journal, 24 (3). pp. 1314-1320. ISSN 1985-4668; ESSN: 2231-7546


The environmental toxicants such as copper are known to affect vital organ especially liver. This study examined the effects of copper sulfate (CuSO4) on the liver morphological structure of P. javanicus. The untreated control, 0.1 and 0.3 mg/L CuSO4 treated groups displayed normal polygonal structure of the hepatocyte. However, at the concentrations of 0.5, 1.0 and 5.0 mg/L CuSO4, the hepatostructure was significantly affected, as shown by the increasing number of dilation and congestion of sinusoids, vacuolation, macrophage activities and peliosis. The damage level and HSI value were increased while the number of hepatic nuclei per mm2 was decreased with the increasing of copper concentration. In conclusion, this study shows that the degree of liver damage in P.javanicus is dependent to the dose exposure.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Publisher: Faculty of Food Science and Technology, Universiti Putra Malaysia
Keywords: Morphology; Hepatocyte; Copper; Puntius javanicus
Depositing User: Nabilah Mustapa
Date Deposited: 12 Jan 2018 04:10
Last Modified: 12 Jan 2018 04:10
URI: http://psasir.upm.edu.my/id/eprint/58362
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