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Nanocrystalline cellulose, an environmental friendly nanoparticle for pharmaceutical application – a quick study


Song, Yee Kai and Chew, Irene Mei Leng and Choong, Thomas Shean Yaw and Tan, Khang Wei (2016) Nanocrystalline cellulose, an environmental friendly nanoparticle for pharmaceutical application – a quick study. In: 2016 3rd International Conference on Chemical and Biological Sciences (ICCBS 2016), 23-25 Mar. 2016, Amsterdam, Netherlands. (pp. 1-5).


Nanocrystalline cellulose (NCC) is probably the most abundant nano material can be found in nature. It offers not only substantial environmental advantage due to its intrinsic biocompatibility and biodegradability, but also outstanding aspect ratio, tension modulus, bioavailability and permeability. NCC can be isolated from low value biomass through a well-developed acid hydrolysis method, and the structure can be readily manipulated during extraction to obtain desirable size distribution, surface charge and degree of crystallinity. Erratic absorption of drug has been a major issue for years until the emergence of nanoparticle adopted as smart vehicle for drug delivery. However, due to inevitably severe toxicity and the side effect from ordinary nanoparticle, the exploration of green nanoparticles are catching escalating attention is now in urge. Microcrystalline cellulose (MCC) has long been an option, nevertheless, due to their relatively low surface charge compared to total volume, drug release in a control manner was hardly satisfied. It is suggested that the above limitation can be overcome by nanocrystalline cellulose. This article discusses and explores their potential in cosmetic, personal care and pharmaceutical application, and the recent development in term of preparation and characteristic.

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Additional Metadata

Item Type: Conference or Workshop Item (Paper)
Divisions: Faculty of Engineering
DOI Number: https://doi.org/10.1051/matecconf/20166001006
Publisher: EDP Sciences
Keywords: Nanocrystalline cellulose; Pharmaceutical application; Nanoparticle
Depositing User: Nabilah Mustapa
Date Deposited: 24 Oct 2017 09:08
Last Modified: 24 Oct 2017 09:08
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1051/matecconf/20166001006
URI: http://psasir.upm.edu.my/id/eprint/57649
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