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Nanoparticle preparation of mefenamic acid by electrospray drying


Zolkepali, Nurul Karimah and Abu Bakar, Noor Fitrah and Naim, Mohd Nazli and Anuar, Nornizar and Abu Bakar, Mohd Rushdi (2013) Nanoparticle preparation of mefenamic acid by electrospray drying. In: 5th Nanoscience and Nanotechnology Symposium (NNS 2013), 23-25 Oct. 2013, Surabaya, Indonesia. (pp. 113-118).


Nanoparticles preparation of Mefenamic acid (MA) by using an electrospray drying method was conducted in this study. Electrospray drying is a process that uses electrostatic force to disperse a conductive liquid stream into fine charged droplets through the coulomb fission of charges in the liquid and finally dry into fine particles. Electrospray drying modes operation usually in Taylor cone jet, and it was formed by controlling applied voltage and liquid flow rate. A conductive liquid (2.77–8.55μScm−1) which is MA solution was prepared by using acetone with concentration 0.041 and 0.055 M before pumping at a flow rate of 3–6ml/h. By applying the applied voltage at 1.3–1.5 kV, Taylor cone jet mode was formed prior to the electrospray. During electrospray drying process, solvent evaporation from the droplet was occurring that leads to coulomb disruption and may generate to nanoparticles. The dried nanoparticles were collected on a grounded substrate that was placed at varying distance from the electrospray. MA particle with size range of 100–400 nm were produced by electrospray drying process. Characterization of particles by using X-ray diffractometry (XRD) and differential scanning calorimetry (DSC) show that particles formed into polymorph I.

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Additional Metadata

Item Type: Conference or Workshop Item (Paper)
Divisions: Faculty of Engineering
DOI Number: https://doi.org/10.1063/1.4866742
Publisher: AIP Publishing LLC
Keywords: Coulomb fission; Electrospray drying; Nanoparticles
Depositing User: Nabilah Mustapa
Date Deposited: 24 Oct 2017 07:34
Last Modified: 24 Oct 2017 07:34
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1063/1.4866742
URI: http://psasir.upm.edu.my/id/eprint/57601
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