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Synthesis, characterization and biological studies of S- benzyl-b-N-(benzoyl)dithiocarbazate and its metal complexes


Citation

How, Fiona Ni Foong and Crouse, Karen Anne and Mohamed Tahir, Mohamed Ibrahim and Tarafder, Md. Tofassa Hossain and Cowley, Andrew R. (2008) Synthesis, characterization and biological studies of S- benzyl-b-N-(benzoyl)dithiocarbazate and its metal complexes. Polyhedron, 27 (15). pp. 3325-3329. ISSN 0277-5387

Abstract

S-Benzyl-b-N-(benzoyl) dithiocarbazate (SBNBODTC) a new disubstituted dithio-carbazate oxygen–sulfur (OS) donor ligand derived from reaction of S-benzyl dithiocarbazate with benzoyl chloride, formed bischelated complexes of general formula [M(OS)2] where M is Cu2+, Ni2+, Cd2+, Co2+ or Pb2+ and OS is a uninegative bidentate ligand. The ligand and its metal complexes have been characterized by a variety of physico-chemical techniques. S-benzyl-b-N-(benzoyl) dithiocarbazate crystallized with Z0 = 2 in its thione form in cis–cis conformation, with the N–N bond adopting a cis geometry with respect to C@S, while the S-benzyl group adopts a cis geometry with respect to the thione sulfur atom across the C–S bond.SBNBODTC, Cu(OS)2, Ni(OS)2 and Pb(OS)2 display marked cytotoxicity against HL-60 (human myeloid leukemia)while Cd(OS)2 and Co(OS)2 are moderately cytotoxic. The compounds showed moderate but selective activity towards targeted pathogens.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
DOI Number: https://doi.org/10.1016/j.poly.2008.07.022
Publisher: Elsevier
Keywords: Dithiocarbazate, Metal complex, Bidentate ligand, Bis-chelated
Depositing User: Najwani Amir Sariffudin
Date Deposited: 30 Apr 2010 03:51
Last Modified: 17 Sep 2015 01:33
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.poly.2008.07.022
URI: http://psasir.upm.edu.my/id/eprint/5690
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