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Silicon nanowire interface circuit for DNA detection


Citation

Usman, Kamilu Iman and Hamidon, Mohd Nizar and Abd Rahman, Siti Fatimah and Sim, Guan Ling (2017) Silicon nanowire interface circuit for DNA detection. Pertanika Journal of Science & Technology, 25 (spec. Feb.). pp. 251-258. ISSN 0128-7680; ESSN: 2231-8526

Abstract / Synopsis

Detection and quantification of DNA is critical to many areas of life sciences and health care, from disease diagnosis to drug screening. The transduction of DNA through electrochemical methods have a fast response rate and with a conductometric device like the silicon nanowire which can be fabricated to have a similar diameter of the DNA molecule being targeted, detection is real-time. Critical to this is the interfacing of a current-source and an amplifier capable of achieving a maximum of 10 pico ampere input bias. In this project, we fabricated a silicon nanowire using the top down approach and built a circuit that can mimic the output signal as low as 12 nA and achieved a gain of 1 million to be interfaced with the nanowire for real-time DNA detection.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Engineering
Institute of Advanced Technology
Publisher: Universiti Putra Malaysia Press
Keywords: Silicon nanowire; Nanoelectronics; Interface circuit; DNA detection
Depositing User: Nabilah Mustapa
Date Deposited: 30 Jun 2017 17:50
Last Modified: 05 Jul 2017 11:35
URI: http://psasir.upm.edu.my/id/eprint/55881
Statistic Details: View Download Statistic

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