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Does high public health expenditure slow down economic growth?


Sirag, Abdalla and Mohamed Nor, Norashidah and Raja Abdullah, Nik Mustapha and Karimi, Mohammad (2016) Does high public health expenditure slow down economic growth? Journal of Applied Economic Sciences, 11 (1(39)). pp. 5-17. ISSN 1843-6110


The Fritillaria imperialis is an ornamental flower that can be found in various parts of the world including Iraq, Afghanistan, Pakistan, and the Himalayas. The use of this plant as traditional remedy is widely known. This study aims to unveil the anti-cancer potentials of Isopimara-7,15-Dien-19-Oic Acid, extracted from the bulbs of F. imperialis in cervical cancer cell line, HeLa cells. Flow cytometry analysis of cell death, gene expression analysis via cDNA microarray and protein array were performed. Based on the results, Isopimara-7,15-Dien-19-Oic acid simultaneously induced cell death and promoted cell survival. The execution of apoptosis was apparent based on the flow cytometry results and regulation of both pro and anti-apoptotic genes. Additionally, the regulation of anti-oxidant genes were up-regulated especially thioredoxin, glutathione and superoxide dismutase- related genes. Moreover, the treatment also induced the activation of pro-survival heat shock proteins. Collectively, Isopimara-7,15-Dien-19-Oic Acid managed to induce cellular stress in HeLa cells and activate several anti- and pro survival pathways.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Economics and Management
Publisher: ASERS Publishing
Keywords: Public health expenditure; Life expectancy; Economic growth; Dynamic panel threshold
Depositing User: Mohd Hafiz Che Mahasan
Date Deposited: 14 Aug 2017 10:03
Last Modified: 14 Aug 2017 10:03
URI: http://psasir.upm.edu.my/id/eprint/55560
Statistic Details: View Download Statistic

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