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Discrimination and nitric oxide inhibitory activity correlation of ajwa dates from different grades and origin


Abdul Hamid, Nur Ashikin and Mediani, Ahmed and Maulidiani, M. and Abas, Faridah and Ismail, Intan Safinar and Shaari, Khozirah and Lajis, Nordin (2016) Discrimination and nitric oxide inhibitory activity correlation of ajwa dates from different grades and origin. Molecules, 21 (11). pp. 1-14. ISSN 1420-3049


This study was aimed at examining the variations in the metabolite constituents of the different Ajwa grades and farm origins. It is also targeted at establishing the correlations between the metabolite contents and the grades and further to the nitric oxide (NO) inhibitory activity. Identification of the metabolites was generated using ¹H-NMR spectroscopy metabolomics analyses utilizing multivariate methods. The NO inhibitory activity was determined using a Griess assay. Multivariate data analysis, for both supervised and unsupervised approaches, showed clusters among different grades of Ajwa dates obtained from different farms. The compounds that contribute towards the observed separation between Ajwa samples were suggested to be phenolic compounds, ascorbic acid and phenylalanine. Ajwa dates were shown to have different metabolite compositions and exhibited a wide range of NO inhibitory activity. It is also revealed that Ajwa Grade 1 from the al-Aliah farm exhibited more than 90% NO inhibitory activity compared to the other grades and origins. Phenolic compounds were among the compounds that played a role towards the greater capacity of NO inhibitory activity shown by Ajwa Grade 1 from the al-Aliah farm.

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Official URL or Download Paper: http://www.mdpi.com/1420-3049/21/11/1423

Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
Faculty of Science
Institute of Bioscience
DOI Number: https://doi.org/10.3390/molecules21111423
Publisher: MDPI
Keywords: Phoenix dactylifera; Ajwa dates; RAW 264.7 cells; NMR metabolomics; Nitric oxide
Depositing User: Mohd Hafiz Che Mahasan
Date Deposited: 14 Aug 2017 10:41
Last Modified: 14 Aug 2017 10:41
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/molecules21111423
URI: http://psasir.upm.edu.my/id/eprint/55541
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