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Differential effects of calcium- and vitamin D-fortified milk with FOS-inulin compared to regular milk, on bone biomarkers in Chinese pre- and postmenopausal women


Citation

Kruge, Marlena C. and Chan, Yoke Mun and Sherlock, Barbara Kuhn and Lau, Lee Ting and Lau, Chin Chin and Chin, Y. S. and Todd, Joanne M. and Schollum, Linda M. (2016) Differential effects of calcium- and vitamin D-fortified milk with FOS-inulin compared to regular milk, on bone biomarkers in Chinese pre- and postmenopausal women. European Journal of Nutrition, 55 (5). pp. 1911-1921. ISSN 1436-6207; ESSN: 1436-6215

Abstract / Synopsis

PURPOSE: To compare the effects of a high-calcium vitamin D-fortified milk with added FOS-inulin versus regular milk on serum parathyroid hormone, and bone turnover markers in premenopausal (Pre-M) and postmenopausal (PM) women over 12 weeks. METHODS: Premenopausal women (n = 136, mean age 41 (±5) years) and postmenopausal women [n = 121, mean age 59 (±4) years] were recruited, and each age group randomised into two groups to take two glasses per day of control = regular milk (500 mg calcium per day) or intervention (Int) = fortified milk (1000 mg calcium for pre-M women and 1200 mg calcium for PM women, 96 mg magnesium, 2.4 mg zinc, 15 µg vitamin D, 4 g FOS-inulin per day). At baseline, week 4 and week 12 serum minerals and bone biochemical markers were measured and bone density was measured at baseline. RESULTS: Mean 25-hydroxyvitamin D [25(OH) vitamin D3] levels among groups were between 49 and 65 nmol/L at baseline, and over the 12 weeks of supplementation, the fortified milk improved vitamin D status in both Int groups. CTx-1 and PINP reduced significantly in both Pre-M and PM groups over the 12 weeks, with the changes in CTx-1 being significantly different (P < 0.035) between PM control and PM Int groups at week 12. Parathyroid hormone levels were significantly reduced in all groups over time, except for control PM group where levels increased at 12 weeks. CONCLUSION: The overall pattern of responses indicates that while both regular milk and fortified milk reduce bone resorption in young and older women, fortified milk is measurably more effective.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Gerontology
DOI Number: https://doi.org/10.1007/s00394-015-1007-x
Publisher: Springer
Keywords: 25(OH) vitamin D3; Bone markers; Bone turnover; Calcium-fortified milk; Chinese women; Malaysia; Postmenopausal women; Premenopausal women; Vitamin D status
Depositing User: Mohd Hafiz Che Mahasan
Date Deposited: 13 Sep 2017 13:12
Last Modified: 14 Sep 2017 09:29
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s00394-015-1007-x
URI: http://psasir.upm.edu.my/id/eprint/55521
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