UPM Institutional Repository

Development of alginate – gum arabic beads for targeted delivery of protein


Mohamed, Hajaratul Najwa and Mustafa, Shuhaimi and Fitrianto, Anwar and Abd Manap, Yazid (2017) Development of alginate – gum arabic beads for targeted delivery of protein. Journal of Biomolecular Research and Therapeutics, 3 (1). pp. 486-508. ISSN 2167-7956


Controlled release beads were prepared by using the combination of alginate and gum Arabic through ionotropic gelation method. Bovine serum albumin was used as model protein for in vitro assessments. The effect of amount of sodium alginate and gum Arabic as the factor affecting protein encapsulation efficiency and protein release were optimized and analyzed by using RSM-FCCD. It was observed that protein encapsulation efficiency was increased and protein release was decreased with the increase of both of the amount of sodium alginate and gum Arabic, used as polymer blend. The optimized beads showed high encapsulation efficiency (87.5 ± 3.65%) with suitable protein release (100% protein release after almost 4 hrs). The swelling of beads were highly influenced by pH of dissolution medium. These beads were also characterized by FT-IR spectroscopy, SEM and TA for protein-excipients interaction, beads surface morphology and beads strength, respectively. These calcium alginate/gum Arabic beads have good potential to be used as delivery vehicle for protein drugs.

Download File

PDF (Abstract)
Development of alginate–gum Arabic beads for targeted delivery of protein.pdf

Download (88kB) | Preview
Official URL or Download Paper: http://www.omicsgroup.org/journals/jbmrthome.php

Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
Faculty of Science
Halal Products Research Institute
DOI Number: https://doi.org/10.4172/2167-7956.1000155
Publisher: Omics Publishing Group
Keywords: Alginate; Gum arabic; Controlled release; Encapsulation; Targeted delivery
Depositing User: Mohd Hafiz Che Mahasan
Date Deposited: 05 Oct 2017 03:19
Last Modified: 05 Oct 2017 03:19
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.4172/2167-7956.1000155
URI: http://psasir.upm.edu.my/id/eprint/55489
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item