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Bis(phosphane)copper(I) and silver(I) dithiocarbamates: crystallography and anti-microbial assay


Jamaludin, Nazzatush Shimar and Abdul Halim, Siti Nadiah and Chai, Hoon Khoo and Chen, Bao Jing and See, Tian Hong and Sim, Jiun Horng and Cheah, Yoke Kqueen and Seng, Hoi Ling and Tiekink, Edward R. T. (2016) Bis(phosphane)copper(I) and silver(I) dithiocarbamates: crystallography and anti-microbial assay. Zeitschrift fur Kristallographie Crystalline Materials , 231 (6). pp. 341-349. ISSN 2194-4946; ESSN: 2196-7105


The crystal and molecular structures of (Ph3P)2M[S2CN(Me)CH2CH2OH], M=Cu, isolated as a 1:1 dichloromethane solvate (1·CH2Cl2), and M=Ag (4) show the central metal atom to be coordinated by a symmetrically (1·CH2Cl2) and asymmetrically chelating (4) dithiocarbamate ligand. The distorted tetrahedral geometries are completed by two PPh3 ligands. The presence of hydroxyl-–···S(dithiocarbamate) hydrogen bonds leads to centrosymmetric dimeric aggregates in each crystal structure. In the molecular packing of 1·CH2Cl2, channels comprising 1 are formed via aryl-C–H···O interactions with the solvent molecules associated with the walls of the channels via methylene-C–H···S, π(aryl) interactions. For 4, the dimeric aggregates are connected via a network of aryl-C–H···π(aryl) interactions. Preliminary screening for anti-microbial activity was conducted. The compounds were only potent against Gram-positive bacteria. Some further selectivity in activity was noted. Most notably, all compounds were active against methicillin resistant Staphylococcus aureus.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1515/zkri-2016-0003
Publisher: Oldenbourg Wissenschaftsverlag
Keywords: Copper(I); Crystal structure analysis; Dithiocarbamate; Silver(I); X-ray diffraction
Depositing User: Ms. Nida Hidayati Ghazali
Date Deposited: 30 Nov 2017 10:02
Last Modified: 30 Nov 2017 10:02
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1515/zkri-2016-0003
URI: http://psasir.upm.edu.my/id/eprint/55211
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