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Antimicrobial stewardship program in a Malaysian district hospital: first year experience


Yap, Diana Fui Sing and Yang, Liang Boo and Mukhlis, Roshalina and Pek, Woon Chin and Fan, Kee Hoo (2016) Antimicrobial stewardship program in a Malaysian district hospital: first year experience. Pakistan Journal of Medical Sciences, 32 (4). pp. 999-1004. ISSN 1682-024X; ESSN: 1681-715X


Backgrounds & Objective: Antimicrobial resistance is an alarming public health threat that requires urgent global solution. Implementation of antimicrobial stewardship program (ASP) is an essential practice element for healthcare institutions in gate-keeping judicious antimicrobial use. This study highlighted the development, first year experience, and result of the implementation of ASP utilizing persuasive and restrictive approaches in a Malaysian district hospital. Methods: An observational study was conducted between January 2015 to December 2015 on implementation of ASP among hospitalized inpatients age 12 years old and above. Results: Recommendations were provided for 60% of cases (110 patients) with the average acceptance rate of 83.33%. Majority of the interventions were to stop the antimicrobial therapy (30.3%), and the most common audited antimicrobials was Piperacillin/ Tazobactam (25.5%), followed by Meropenem (11.82%), Amoxicillin/Clavulanate and Vancomycin (8.18%) respectively. The concordance rate towards authorization policy was increased in 2015 (71.59% of cases) as compared before the implementation of ASP in 2014 (60.6% of cases). Restrictive enforcement under ASP had been shown to improve significantly adherence rate towards antimicrobials authorization policy (p-value: 0.004). Conclusion: ASP was successfully implemented in a district hospital. Future studies on its clinical outcomes are important to evaluate its effectiveness as well as focus on the improvement to the pre-existing strategies and measures.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.12669/pjms.324.9855
Publisher: Professional Medical Publications
Keywords: Antimicrobial stewardship; Anti-Infective agents; Drug resistance; Malaysia; Rural hospital
Depositing User: Ms. Nida Hidayati Ghazali
Date Deposited: 29 Dec 2017 05:46
Last Modified: 29 Dec 2017 05:46
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.12669/pjms.324.9855
URI: http://psasir.upm.edu.my/id/eprint/55086
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