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Anti-diabetic activity and metabolic changes induced by Andrographis paniculata plant extract in obese diabetic rats


Citation

Akhtar, Muhammad Tayyab and Mohd Sarib, Mohamad Syakir and Ismail, Intan Safinar and Abas, Faridah and Ismail, Amin and Lajis, Nordin and Shaari, Khozirah (2016) Anti-diabetic activity and metabolic changes induced by Andrographis paniculata plant extract in obese diabetic rats. Molecules, 21 (8). art. no. 1026. pp. 1-18. ISSN ; ESSN: 1420-3049

Abstract / Synopsis

Andrographis paniculata is an annual herb and widely cultivated in Southeast Asian countries for its medicinal use. In recent investigations, A. paniculata was found to be effective against Type 1 diabetes mellitus (Type 1 DM). Here, we used a non-genetic out-bred Sprague-Dawley rat model to test the antidiabetic activity of A. paniculata against Type 2 diabetes mellitus (Type 2 DM). Proton Nuclear Magnetic Resonance (1H-NMR) spectroscopy in combination with multivariate data analyses was used to evaluate the A. paniculata and metformin induced metabolic effects on the obese and obese–diabetic (obdb) rat models. Compared to the normal rats, high levels of creatinine, lactate, and allantoin were found in the urine of obese rats, whereas, obese-diabetic rats were marked by high glucose, choline and taurine levels, and low lactate, formate, creatinine, citrate, 2-oxoglutarate, succinate, dimethylamine, acetoacetate, acetate, allantoin and hippurate levels. Treatment of A. paniculata leaf water extract was found to be quite effective in restoring the disturbed metabolic profile of obdb rats back towards normal conditions. Thisstudy shows the anti-diabetic potential of A. paniculata plant extract and strengthens the idea of using this plant against the diabetes. Further classical genetic methods and state of the art molecular techniques could provide insights into the molecular mechanisms involved in the pathogenesis of diabetes mellitus and anti-diabetic effects of A. paniculata water extract.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.3390/molecules21081026
Publisher: MDPI
Keywords: Andrographis paniculata; Metabolomics; Diabetes; Obesediabetic rat; Type 2 DM; NMR
Depositing User: Nida Hidayati Ghazali
Date Deposited: 19 Jan 2018 12:24
Last Modified: 19 Jan 2018 12:24
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/molecules21081026
URI: http://psasir.upm.edu.my/id/eprint/55081
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