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Antidepressant-like effect of lipid extract of Channa striatus in chronic unpredictable mild stress model of depression in rats


Citation

Abdul Shukkoor, Mohamed Saleem and Baharuldin, Mohamad Taufik Hidayat and Mat Jais, Abdul Manan and Mohamad Moklas, Mohamad Aris and Fakurazi, Sharida (2016) Antidepressant-like effect of lipid extract of Channa striatus in chronic unpredictable mild stress model of depression in rats. Evidence-Based Complementary and Alternative Medicine . art. no. 2986090. pp. 1-17. ISSN 1741-4288

Abstract / Synopsis

This study evaluated the antidepressant-like effect of lipid extract of C. striatus in chronic unpredictablemild stress (CUMS)model of depression in male rats and its mechanism of action. The animals were subjected to CUMS for six weeks by using variety of stressors. At the end of CUMS protocol, animals were subjected to forced swimming test (FST) and open field test followed by biochemical assay. The CUMS protocol produced depressive-like behavior in rats by decreasing the body weight, decreasing the sucrose preference, and increasing the duration of immobility in FST. The CUMS protocol increased plasma corticosterone and decreased hippocampal and prefrontal cortex levels of monoamines (serotonin, noradrenaline, and dopamine) and brain-derived neurotrophic factor. Further, the CUMS protocol increased interleukin-6 (in hippocampus and prefrontal cortex) and nuclear factor-kappa B (in prefrontal cortex but not in hippocampus).The lipid extract of C. striatus (125, 250, and 500mg/kg) significantly (


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1155/2016/2986090
Publisher: Hindawi Publishing Corporation
Keywords: Channa striatus
Depositing User: Nida Hidayati Ghazali
Date Deposited: 19 Jan 2018 11:54
Last Modified: 19 Jan 2018 11:54
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2016/2986090
URI: http://psasir.upm.edu.my/id/eprint/55080
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