UPM Institutional Repository

Anti-cancer activity of three terminalia species and preliminary phytochemical


Rashed, Khaled and Esa, Norhaizan and Ismail, Salmiah (2016) Anti-cancer activity of three terminalia species and preliminary phytochemical. Jordan Journal of Pharmaceutical Sciences, 9 (3). pp. 175-180. ISSN 1995-7157


This study evaluated anticancer potential of three Terminalia species, Terminalia muelleri, Terminalia bellerica, and Terminalia laxiflora and also their phytochemical content were determined. Anticancer potential of the plant extracts was measured according to MTT assay. The results showed that T. muelleri methanolic extract was active against breast cancer cell line with IC50 40 µg/mL. T. bellerica methanolic extract exerted cytotoxic effects only against colon cancer and liver cancer cell lines with IC50 of 50 and 15µg/mL, respectively. While T. laxiflora methanolic extract did not inhibit the proliferation of all cancer cell lines tested. Phytochemical investigation of the three plant species proved the presence of carbohydrates, flavonoids, tannins, and triterpenes. The methanolic extracts of T. muelleri and T. bellerica had a significant anticancer activity and so further phytochemical study to isolate and identify the bioactive molecules responsible for the observed anticancer activity is necessary.

Download File

Text (Abstract)
Anti-cancer activity of three terminalia species and preliminary phytochemical .pdf

Download (5kB) | Preview

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: University of Jordan
Keywords: Terminalia species; Bark; Anticancer; Phyto-constituents
Depositing User: Mohd Hafiz Che Mahasan
Date Deposited: 13 Aug 2018 07:55
Last Modified: 13 Aug 2018 07:55
URI: http://psasir.upm.edu.my/id/eprint/55078
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item