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Kojic acid esters: comparative review on its methods of synthesis


Ishak, Nurazwa and Lajis, Ahmad Firdaus and Mohamad, Rosfarizan and Ariff, Arbakariya and Halim, Murni and Wasoh @ Mohamad Isa, Helmi (2016) Kojic acid esters: comparative review on its methods of synthesis. Journal of Biochemistry, Microbiology and Biotechnology, 4 (2). pp. 7-15. ISSN 2289-5779


In this paper, the syntheses of kojic acid esters via chemical and enzymatic methods are reviewed. The advantages and disadvantages of chemical process in term of process, safety and efficiency are discussed. In enzymatic process, the significant process parameters related to the synthesis of kojic acid esters such as the lipases, solvent, temperature and water content are highlighted. Possible enzymatic synthesis using solvent and solvent-free system taking into consideration of the difference in these systems involving cost, lipase reusability and efficiency is comparatively reviewed. The possible approach for large scale production using various enzyme reactor designs is also discussed and re-evaluated.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Publisher: Hibiscus Publisher
Keywords: Kojic acid derivatives; Organic synthesis; Solvent-free system; Biological reactors; Lipases
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 19 Apr 2018 01:47
Last Modified: 19 Apr 2018 01:47
URI: http://psasir.upm.edu.my/id/eprint/54683
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